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Showing 1–2 of 2 results
Advanced filters: Author: Sebastian Knüsel Clear advanced filters

  • African trypanosomes collectively move in a process called social motility. Here, the authors show that procyclic forms acidify their environment as a consequence of glucose metabolism, generating pH gradients by diffusion that are sensed via cyclic AMP signalling. Parasite mutants defective in cAMP signaling are inhibited in fly infection.

    • Sebastian Shaw
    • Sebastian Knüsel
    • Isabel Roditi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Trypanosoma brucei probably relies on chemotactic signals for movement through tsetse fly tissues, but the molecular basis is unknown. Here, the authors show that flagellar cAMP signaling is required for traversal of the peritrophic matrix and that, without it, parasites are trapped in the midgut lumen.

    • Sebastian Shaw
    • Stephanie F. DeMarco
    • Kent L. Hill
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13