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Showing 1–3 of 3 results
Advanced filters: Author: Sebastian M. Siegner Clear advanced filters

  • Structural features of DNA double-strand break (DSB) ends play key roles in determining DNA repair pathway usage and outcomes. Here, the authors identify ERCC6L2, a poorly characterized ATPase, as playing a minimal role in blunt end DSB repair but crucial for repair of staggered end DSBs.

    • Eric J. Aird
    • Almudena Serrano-Benitez
    • Stephen P. Jackson
    ResearchOpen Access
    Nature Communications
    Volume: 17, P: 1-19

  • Combinatorial CRISPRi screening was used to map genetic interactions in DNA damage response pathways, revealing known and new connections, including the roles of WDR48 and USP1 in preventing under-replication and SMARCAL1 and FANCM in remodelling persistent cruciform DNA structures.

    • John Fielden
    • Sebastian M. Siegner
    • Jacob E. Corn
    ResearchOpen Access
    Nature
    Volume: 640, P: 1093-1102