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Showing 1–3 of 3 results
Advanced filters: Author: Sebastian Schätzle Clear advanced filters

  • The identification or development of enzymes with new functions remains a significant challenge. A new strategy uses rationally selected sequences anticipated to serve as functional motifs to search the wealth of available genomic data, successfully yielding 17 (R)-selective amine transaminases.

    • Matthias Höhne
    • Sebastian Schätzle
    • Uwe T Bornscheuer
    Research
    Nature Chemical Biology
    Volume: 6, P: 807-813

  • Cathepsin S is responsible for cleaving the invariant chain Ii for the presentation of peptides by major histocompatibility complex class II on DCs. Diamond and colleagues show that the transcription factor Blimp-1 negatively regulates expression of cathepsin S and influences selection of the TFH cell repertoire and autoantibody-producing B cells.

    • Sun Jung Kim
    • Sebastian Schätzle
    • Betty Diamond
    Research
    Nature Immunology
    Volume: 18, P: 1016-1024

  • In this Resource paper, the authors integrate T cell antigen receptor, B cell antigen receptor and exome sequencing comparing early and metastatic breast cancer in humans, showing how the immune response and tumors coevolve.

    • Stephen-John Sammut
    • Jacob D. Galson
    • Rachael J. M. Bashford-Rogers
    ResearchOpen Access
    Nature Immunology
    Volume: 25, P: 916-924