Nature Search

Myeloperoxidase transforms chromatin into neutrophil extracellular traps

Myeloperoxidase, a highly expressed neutrophil protein, disassembles nucleosomes, facilitating neutrophil extracellular trap (NET) formation, and binds stably to NETs extracellularly.

Garth Lawrence Burn
Tobias Raisch
Arturo Zychlinsky
ResearchOpen Access17 Sept 2025
Nature

Volume: 647, P: 747-756
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD

Chronic obstructive pulmonary disease is a progressive and incurable chronic condition that involves accumulation of inflammatory macrophages in the lung tissue. Authors here show in mouse models of lung disease that PRMT7, a protein arginine methyltransferase, is an important regulator of recruitment and the pro-inflammatory phenotype of macrophages.

Gizem Günes Günsel
Thomas M. Conlon
Ali Önder Yildirim
ResearchOpen Access14 Mar 2022
Nature Communications

Volume: 13, P: 1-21
Structure of the native myosin filament in the relaxed cardiac sarcomere

A cryo-electron tomography study reports the structure of thick myosin filaments of mouse cardiac muscle in the relaxed state in situ and the MyBP-C links that connect them with the surrounding thin actin filaments.

Davide Tamborrini
Zhexin Wang
Stefan Raunser
ResearchOpen Access01 Nov 2023
Nature

Volume: 623, P: 863-871
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Human resident liver myeloid cells protect against metabolic stress in obesity

Barreby et al. identify a distinct subpopulation of human resident liver myeloid cells that expresses factors that act in a protective fashion against oxidative stress associated with NAFLD.

Emelie Barreby
Benedikt Strunz
Myriam Aouadi
ResearchOpen Access06 Jul 2023
Nature Metabolism

Volume: 5, P: 1188-1203
Mutated tumor alleles are expressed according to their DNA frequency

John C. Castle
Martin Loewer
Ugur Sahin
ResearchOpen Access22 Apr 2014
Scientific Reports

Volume: 4, P: 1-6
Needs assessment for creation of a platform trial network in metabolic-dysfunction associated steatohepatitis

Sena et al. survey European clinical research sites that could potentially serve as the foundation for a MASH integrated research platform and clinical research network. Respondents generally believe that a MASH platform trial could benefit patients and are interested in participating, though securing industry funding is identified as a priority.

Elena Sena
Frank Tacke
Juan M. Pericàs
ResearchOpen Access16 Jul 2024
Communications Medicine

Volume: 4, P: 1-8
SPHIRE-crYOLO is a fast and accurate fully automated particle picker for cryo-EM

Thorsten Wagner et al. present SPHIRE-crYOLO, a particle picking software for selecting particles from digital micrographs in cryoEM data. After training, the method automatically recognizes particles with high recall and precision, simplifying data pre-processing.

Thorsten Wagner
Felipe Merino
Stefan Raunser
ResearchOpen Access19 Jun 2019
Communications Biology

Volume: 2, P: 1-13
Seven weeks of Western diet in apolipoprotein-E-deficient mice induce metabolic syndrome and non-alcoholic steatohepatitis with liver fibrosis

Robert Schierwagen
Lara Maybüchen
Jonel Trebicka
ResearchOpen Access11 Aug 2015
Scientific Reports

Volume: 5, P: 1-14

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