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Showing 1–4 of 4 results
Advanced filters: Author: Sebastien Janel Clear advanced filters

  • Uropathogenic strains of Escherichia coli (UPEC) are a leading cause of urinary tract infections (UTIs) and invasion involves Rho GTPase members, notably Rac1, to drive actin cytoskeleton rearrangement leading to engulfment. Here, Petracchini et al. provide evidence of an ECM stiffnessmodulated role of Optineurin (OPTN), which regulates HACE1-dependant Rac1 activity and thus controls integrinmediated mechanotransduction and bacterial invasion.

    • Serena Petracchini
    • Daniel Hamaoui
    • Amel Mettouchi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-22

  • Neisseria meningitidis bacteria bind to host proteins CD147 and β2-adrenergic receptor on the surface of endothelial cells. Here, Maïssa et al. show that the two proteins interact with each other forming clusters that increase the binding strength of the bacteria to endothelial cells.

    • Nawal Maïssa
    • Valentina Covarelli
    • Sandrine Bourdoulous
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-15

  • Holes in endothelial barriers, called transendothelial cell macroapertures (TEMs), are predicted to be limited by line tension of unknown origin. Here the authors identify an actomyosin cable encircling TEMs and establish a role for ezrin in stabilising F-actin bundles, allowing their crosslinking by non-muscle myosin IIa.

    • Caroline Stefani
    • David Gonzalez-Rodriguez
    • Emmanuel Lemichez
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14

  • Neisseria meningitidis is the causative agent of potentially fatal meningitis and septic shock, induced by bacterial colonization of blood vessels in the brain and the periphery. The endothelial cell receptor mediating meningococcal adhesion to blood vessels has previously been unknown. Here Sandrine Bourdoulous and colleagues report that CD147 expressed on human endothelial cells is a crucial mediator of N. meningitidis vascular colonization, providing new insight into some of the mechanisms that give rise to meningococcal disease.

    • Sandra C Bernard
    • Nandi Simpson
    • Sandrine Bourdoulous
    Research
    Nature Medicine
    Volume: 20, P: 725-731