Due to the difference between rodent, porcine and human nerve morphology, Gupta et al. propose an integrative approach of computational modelling and ex vivo electrophysiology studies to identify clinically relevant optimal parameters for human peripheral nerve stimulation as a therapeutic tool. The agreement between results validate the use of computer simulations as a first step toward determining stimulation parameters to provide input criteria for device design and dose selection prior to first-in-human trials.
- Isha Gupta
- Antonino M. Cassará
- Daniel J. Chew
