Although germline removal normally extends Caenorhabditis elegans lifespan, Lee et al. show that low temperature does not extend lifespan in germline-lacking mutant worms. Cold temperatures (10 °C, 15 °C) delay germline stem cell exhaustion, releasing prostaglandin E2 hormone, which induces cbs-1 in the intestine to produce hydrogen sulfide and prolong lifespan.
- Hyun Ju Lee
- Alireza Noormohammadi
- David Vilchez
