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Induction of T-helper-17-cell-mediated anti-tumour immunity by pathogen-mimicking polymer nanoparticles

Intra-tumourally injected hollow nanoparticles displaying the polysaccharide mannan downregulate the fraction of regulatory T cells in the tumour microenvironment and induce anti-tumour responses mediated by T helper 17 cells.

Sejin Son
Jutaek Nam
James J. Moon
Research23 Dec 2022
Nature Biomedical Engineering

Volume: 7, P: 72-84
Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer

Photothermal therapy (PTT) for cancer treatment is currently limited to local, accessible, tumors. Here the authors show that PTT combination with chemotherapy, by stimulating an immune response, is effective against distant tumors and establishes immune memory, thus providing a strategy to target metastatic disease.

Jutaek Nam
Sejin Son
James J. Moon
ResearchOpen Access14 Mar 2018
Nature Communications

Volume: 9, P: 1-13
Cancer nanomedicine for combination cancer immunotherapy

Cancer nanomedicine in combination with immunotherapies offers the possibility to amplify antitumour immune responses and to sensitize tumours to immunotherapies. In this Review, the authors discuss combination immunotherapy based on nanoparticle platforms designed for chemotherapy, photothermal therapy, photodynamic therapy, radiotherapy and gene therapy.

Jutaek Nam
Sejin Son
James J. Moon
Reviews26 Apr 2019
Nature Reviews Materials

Volume: 4, P: 398-414
Author Correction: Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts

Sung-Jin Bae
Min Wook Shin
Kyu-Won Kim
Amendments and CorrectionsOpen Access04 Jun 2025
Experimental & Molecular Medicine

Volume: 57, P: 1339-1340
Engineered polysaccharides for controlling innate and adaptive immune responses

Polysaccharides possess immune-activating or immune-regulatory functions and can thus be applied as immunomodulators. This Review discusses engineering approaches for the design of polysaccharides for vaccine, immunoadjuvant, immune-modulation and drug-delivery applications.

Jutaek Nam
April Kim
Sejin Son
Reviews18 Jun 2024
Nature Reviews Bioengineering

Volume: 2, P: 733-751
Glycol chitosan nanoparticles as specialized cancer therapeutic vehicles: Sequential delivery of doxorubicin and Bcl-2 siRNA

Hong Yeol Yoon
Sejin Son
Martin G. Pomper
ResearchOpen Access03 Nov 2014
Scientific Reports

Volume: 4, P: 1-12
Ninjurin1 positively regulates osteoclast development by enhancing the survival of prefusion osteoclasts

Sung-Jin Bae
Min Wook Shin
Kyu-Won Kim
ResearchOpen Access16 Jan 2019
Experimental & Molecular Medicine

Volume: 51, P: 1-16
ROS-generating TiO₂ nanoparticles for non-invasive sonodynamic therapy of cancer

Dong Gil You
V. G. Deepagan
Jae Hyung Park
ResearchOpen Access21 Mar 2016
Scientific Reports

Volume: 6, P: 1-12

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