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Showing 1–2 of 2 results
Advanced filters: Author: Seka S. Lazare Clear advanced filters

  • Rapid diagnosis and implementation of treatments is crucial in many genetic conditions. Here the authors describe Genome-to-Treatment, a virtual disease management system that can achieve a rapid diagnosis by expedited whole genome sequencing in 13.5 hours and provide guidance to clinicians for possible therapies.

    • Mallory J. Owen
    • Sebastien Lefebvre
    • Stephen F. Kingsmore
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • Haematopoietic stem cells (HSCs) are characterized by their self-renewal potential and associated dormancy. Here the authors show that niche produced netrin-1 preserves HSC quiescence and self-renewal via neogenin-1, and that decline of netrin-1 production during ageing leads to decreased Neo1 mediated HSC self-renewal.

    • Simon Renders
    • Arthur Flohr Svendsen
    • Andreas Trumpp
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15