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Increased circulating levels of Factor H-Related Protein 4 are strongly associated with age-related macular degeneration

A locus on chromosome 1 encompassing the CFHR genes is highly associated with AMD risk. Here, Cipriani and colleagues investigate the role of CFHR4, encoding FHR-4, and demonstrate a relationship between AMD risk, circulating FHR-4 levels and genetic variants at this locus.

Valentina Cipriani
Laura Lorés-Motta
Simon J. Clark
ResearchOpen Access07 Feb 2020
Nature Communications

Volume: 11, P: 1-15
FHL-1 interacts with human RPE cells through the α5β1 integrin and confers protection against oxidative stress

Rawshan Choudhury
Nadhim Bayatti
Simon J. Clark
ResearchOpen Access08 Jul 2021
Scientific Reports

Volume: 11, P: 1-17
Elevation of brain glucose and polyol-pathway intermediates with accompanying brain-copper deficiency in patients with Alzheimer’s disease: metabolic basis for dementia

Jingshu Xu
Paul Begley
Garth J. S. Cooper
ResearchOpen Access09 Jun 2016
Scientific Reports

Volume: 6, P: 1-12
C-reactive protein and pentraxin-3 binding of factor H-like protein 1 differs from complement factor H: implications for retinal inflammation

Maurice Swinkels
Justine H. Zhang
Simon J. Clark
ResearchOpen Access26 Jan 2018
Scientific Reports

Volume: 8, P: 1-12

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