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Nature Microbiology (2)
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Advanced filters: Author: Senén D. Mendoza Clear advanced filters

Multigenerational proteolytic inactivation of restriction upon subtle genomic hypomethylation in Pseudomonas aeruginosa

Elevated temperatures inactivate a type I restriction endonuclease in P. aeruginosa for ~60 generations via proteolytic degradation triggered by DNA hypomodification, preventing self-targeting and enabling recovery of restriction activity.

Esther Shmidov
Alexis Villani
Ehud Banin
Research08 Sept 2025
Nature Microbiology

Volume: 10, P: 2498-2510
A bacteriophage nucleus-like compartment shields DNA from CRISPR nucleases

The jumbo phage ΦKZ constructs a proteinaceous nucleus-like compartment around its genome that protects phage DNA from degradation by DNA-targeting immune effectors of the host, including CRISPR–Cas and restriction enzymes.

Senén D. Mendoza
Eliza S. Nieweglowska
Joseph Bondy-Denomy
Research09 Dec 2019
Nature

Volume: 577, P: 244-248
Bacteriophage genome engineering with CRISPR–Cas13a

A phage genetic engineering platform will enable a better understanding of phage biology and engineering of phage therapies.

Jingwen Guan
Agnès Oromí-Bosch
Joseph Bondy-Denomy
Research31 Oct 2022
Nature Microbiology

Volume: 7, P: 1956-1966