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Showing 1–14 of 14 results

Advanced filters: Author: Seokjoong Kim Clear advanced filters

Genotyping with CRISPR-Cas-derived RNA-guided endonucleases

Cas9 RNA-guided engineered nucleases (RGENs) induce site-specific DNA cleavages in cultured cells and organisms and are used widely as genome-editing tools. Here, the authors develop an RGEN-based technology to genotype both RGEN-induced mutations and cancer-associated mutations in human cell lines.

Jong Min Kim
Daesik Kim
Jin-Soo Kim
Research20 Jan 2014
Nature Communications

Volume: 5, P: 1-8
Correction: Corrigendum: Genotyping with CRISPR-Cas-derived RNA-guided endonucleases

Jong Min Kim
Daesik Kim
Jin-Soo Kim
Amendments and Corrections06 Feb 2015
Nature Communications

Volume: 6, P: 1
In vivo genome editing with a small Cas9 orthologue derived from Campylobacter jejuni

The amount of genetic material that can be packaged in AAV vectors used for genome editing is limited. Here the authors show that the smallest known Cas9 orthologue, cjCas9, can be packaged in a single AAV vector along with sgRNA and a marker gene, and demonstrate efficient gene editing in mice.

Eunji Kim
Taeyoung Koo
Jin-Soo Kim
ResearchOpen Access21 Feb 2017
Nature Communications

Volume: 8, P: 1-12
Preassembled zinc-finger arrays for rapid construction of ZFNs

Seokjoong Kim
Mi Jung Lee
Jin-Soo Kim
Correspondence29 Dec 2010
Nature Methods

Volume: 8, P: 7
Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

In vitro digestion of genomic DNA with Cas9 and single guide RNAs (sgRNAs) yields genome-wide off-target sites at frequencies below 0.1%. Off-target sites can be further reduced with modified sgRNAs.

Daesik Kim
Sangsu Bae
Jin-Soo Kim
Research09 Feb 2015
Nature Methods

Volume: 12, P: 237-243
Directed evolution of CRISPR-Cas9 to increase its specificity

Undesired off-target effects can hamper the use of CRISPR-Cas9 in therapeutic applications. Here the authors use a directed evolution approach to develop Sniper-Cas9 which combines high specificity with no loss of on-target activity.

Jungjoon K. Lee
Euihwan Jeong
Jin-Soo Kim
ResearchOpen Access06 Aug 2018
Nature Communications

Volume: 9, P: 1-10
Glucocerebrosidase depletion enhances cell-to-cell transmission of α-synuclein

Transmission of alpha-synuclein aggregates between neurons has been observed in animal models of Parkinson’s disease, however, the mechanism of transmission remains unclear. Bae et al. report that a cycle of uptake, co-aggregation and exocytosis is enhanced by loss of glucocerebrosidase activity.

Eun-Jin Bae
Na-Young Yang
Seung-Jae Lee
Research26 Aug 2014
Nature Communications

Volume: 5, P: 1-11
A library of TAL effector nucleases spanning the human genome

A collection of TALENs targeted to 18,740 human protein-coding genes will facilitate genetic engineering of human cells.

Yongsub Kim
Jiyeon Kweon
Jin-Soo Kim
Research17 Feb 2013
Nature Biotechnology

Volume: 31, P: 251-258
Author Correction : SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease

Hyun Jung Park
Areum Han
Jihwan Song
Amendments and CorrectionsOpen Access21 Apr 2022
npj Regenerative Medicine

Volume: 7, P: 1
Targeted dual base editing with Campylobacter jejuni Cas9 by single AAV-mediated delivery

Jiyeon Kweon
An-Hee Jang
Yongsub Kim
ResearchOpen Access01 Feb 2023
Experimental & Molecular Medicine

Volume: 55, P: 377-384
Erratum: Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation

Eun-Jin Bae
Na Young Yang
Seung-Jae Lee
Amendments and Corrections02 Oct 2015
Experimental & Molecular Medicine

Volume: 47, P: e188
Loss of glucocerebrosidase 1 activity causes lysosomal dysfunction and α-synuclein aggregation

Eun-Jin Bae
Na Young Yang
Seung-Jae Lee
ResearchOpen Access27 Mar 2015
Experimental & Molecular Medicine

Volume: 47, P: e153
SUPT4H1-edited stem cell therapy rescues neuronal dysfunction in a mouse model for Huntington’s disease

Hyun Jung Park
Areum Han
Jihwan Song
ResearchOpen Access19 Jan 2022
npj Regenerative Medicine

Volume: 7, P: 1-11
Statins suppress cell-to-cell propagation of α-synuclein by lowering cholesterol

Joo-Ok Min
Hoang-Anh Ho
Seung-Jae Lee
ResearchOpen Access27 Jul 2023
Cell Death & Disease

Volume: 14, P: 1-13