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Author Correction: A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids

Qingyun Dan
Yan Chiu
Jay D. Keasling
Amendments and CorrectionsOpen Access29 Jan 2026
Nature Catalysis

P: 1
A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Triacetic acid lactone (TAL) is a platform chemical with a wide range of applications. Here, the authors report the discovery of a polyketoacyl-CoA thiolase from Burkholderia sp. RF2-non_BP3, termed as BktBbr, which has unusually high in vivo and in vitro activity for production of TAL.

Zilong Wang
Seokjung Cheong
Jay D. Keasling
ResearchOpen Access09 Dec 2025
Nature Communications

Volume: 16, P: 1-12
Engineering controllable alteration of malonyl-CoA levels to enhance polyketide production

Malonyl-CoA (M-CoA) is essential for polyketide biosynthesis, but its limited availability constrains production. Here the authors engineer and evolve an orthogonal M-CoA pathway in Escherichia coli to improve M-CoA metabolism, increasing M-CoA levels and polyketide yields.

Sarah H. Klass
Mia Wesselkamper
Jay D. Keasling
ResearchOpen Access11 Jun 2025
Nature Chemical Biology

Volume: 21, P: 1214-1225
A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids

Medium- and branched-chain diols and amino alcohols are important industrial feedstocks, but they are biosynthetically challenging to produce. Here the authors introduce a modular polyketide synthase platform for the efficient production of these compounds.

Qingyun Dan
Yan Chiu
Jay D. Keasling
ResearchOpen Access11 Feb 2025
Nature Catalysis

Volume: 8, P: 147-161
Biorenewable and circular polydiketoenamine plastics

A circular economy for plastics offers a promising solution to the pollution crisis. Here the authors take advantage of the unique chemistry of polydiketoenamine resins, showing how plastics can be biorenewable and recyclable by incorporating biosourced triacetic acid lactone.

Jeremy Demarteau
Benjamin Cousineau
Brett A. Helms
Research27 Jul 2023
Nature Sustainability

Volume: 6, P: 1426-1435
A polyketoacyl-CoA thiolase-dependent pathway for the synthesis of polyketide backbones

Polyketide biosynthesis has remained exclusively based on polyketide synthases. Now, it is shown that certain thiolases can be employed instead, providing a method that offers distinct advantages for the synthesis of valuable products.

Zaigao Tan
James M. Clomburg
Ramon Gonzalez
Research22 Jun 2020
Nature Catalysis

Volume: 3, P: 593-603
Energy- and carbon-efficient synthesis of functionalized small molecules in bacteria using non-decarboxylative Claisen condensation reactions

A wide array of functionalized small molecules can be synthesized in Escherichia coli by engineering orthogonal, modular pathways that are energy and carbon efficient.

Seokjung Cheong
James M Clomburg
Ramon Gonzalez
Research18 Apr 2016
Nature Biotechnology

Volume: 34, P: 556-561

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Author Correction: A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids

A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Engineering controllable alteration of malonyl-CoA levels to enhance polyketide production

A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids

Biorenewable and circular polydiketoenamine plastics

A polyketoacyl-CoA thiolase-dependent pathway for the synthesis of polyketide backbones

Energy- and carbon-efficient synthesis of functionalized small molecules in bacteria using non-decarboxylative Claisen condensation reactions

Search

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Author Correction: A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids

A highly active Burkholderia polyketoacyl-CoA thiolase for production of triacetic acid lactone

Engineering controllable alteration of malonyl-CoA levels to enhance polyketide production

A polyketide-based biosynthetic platform for diols, amino alcohols and hydroxy acids

Biorenewable and circular polydiketoenamine plastics

A polyketoacyl-CoA thiolase-dependent pathway for the synthesis of polyketide backbones

Energy- and carbon-efficient synthesis of functionalized small molecules in bacteria using non-decarboxylative Claisen condensation reactions

Search

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