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Showing 1–4 of 4 results
Advanced filters: Author: Sepehr Dehghani-Ghahnaviyeh Clear advanced filters

  • The Spns lipid transporters use ion gradients to drive substrate transport, including bioactive sphingolipids. Here, Dastvan et al. investigated how binding of protons powers the conformational changes that enable broad transport by a bacterial Spns.

    • Reza Dastvan
    • Ali Rasouli
    • Emad Tajkhorshid
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-15

  • CLC-type channels selectively transport Cl− across biological membranes, but it is unclear how discrimination between anions is maintained. Here, authors use a combination of non-natural amino acid substitutions, electrophysiology, and molecular dynamics simulations to determine Cl− specificity within this family of ion channels.

    • Lilia Leisle
    • Kin Lam
    • Alessio Accardi
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-11

  • Structural studies of the native transmembrane channel-like protein 1 (TMC-1) mechanosensory transduction channel complex of Caenorhabditis elegans reveal the subunit composition and the roles of protein–membrane interactions in the conversion of mechanical force to ion channel activity.

    • Hanbin Jeong
    • Sarah Clark
    • Eric Gouaux
    ResearchOpen Access
    Nature
    Volume: 610, P: 796-803