Enhancers are genomic elements critical for regulating gene expression. In this Review, the authors discuss how sequence-to-function models can be used to unravel the rules underlying enhancer activity and function as biological ‘oracles’ aiding the design of synthetic enhancers with tailored cell-type-specific or cell-state-specific activities.
- Seppe De Winter
- Vasileios Konstantakos
- Stein Aerts
