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Showing 1–9 of 9 results
Advanced filters: Author: Seraphine Wegner Clear advanced filters

  • The sequence of specific differentiation signals determines the fate of a pluripotent cell. Here pluripotency was introduced into synthetic cells by loading them with three dormant apo-metalloenzymes, which were activated through selective metal ion transport by one of three ionophores. Depending on the sequence of metal ion intake, the synthetic cells differentiated towards five distinct fates.

    • Sayuri L. Higashi
    • Yanjun Zheng
    • Seraphine V. Wegner
    ResearchOpen Access
    Nature Chemistry
    Volume: 17, P: 54-65

  • Tools for high spatiotemporal control of cell-cell adhesions are lacking. Here, authors propose an optogenetic tool, opto-E-cadherin, that allows reversible control of E-cadherin-mediated cell-cell adhesions with blue light.

    • Brice Nzigou Mombo
    • Brent M. Bijonowski
    • Seraphine V. Wegner
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • The Hedgehog morphogen creates gradients during development, but diffusion alone cannot explain its spatiotemporal dynamics. Hedgehog transport requires binding heparan sulfate sugar chains, and the authors now show that Hedgehogs can spread by interacting with sequential heparan molecules.

    • Fabian Gude
    • Jurij Froese
    • Kay Grobe
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • In this review, we overview the recent advances associated with seminal findings in the development of nucleic acid-based fluorescent sensor systems aimed at application for exploring intracellular phenomena. We described the fluorescence signal generation mechanisms of each nucleic acid-based fluorescent sensor, including molecular beacon and quencher-free linear probes, as well as aptamer or DNAzyme-based systems. In addition, cascade hybridization chain reaction and catalyzed hairpin assembly are introduced as methods for amplifying fluorescence signals under isothermal conditions.

    • Aya Shibata
    • Sayuri L. Higashi
    • Masato Ikeda
    Reviews
    Polymer Journal
    Volume: 54, P: 751-766