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Showing 1–3 of 3 results
Advanced filters: Author: Sergey Mureev Clear advanced filters

  • Subunits of the Elongator complex have been implicated in several nervous system pathologies. Here, the authors identify ELP2 variants in six patients with neurodevelopmental anomalies and show in mouse models that these variants impact protein stability and the activity of the complex during brain development.

    • Marija Kojic
    • Tomasz Gawda
    • Brandon J. Wainwright
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-18

  • Generic approach for rapid prototyping is essential for the progress of synthetic biology. Here the authors modify the cell-free translation system to control protein aggregation and folding and validate the approach by using single conditions for prototyping of various disulfide-constrained polypeptides.

    • Yue Wu
    • Zhenling Cui
    • Sergey Mureev
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-17

  • Elp6 is a component of the Elongator complex that regulates tRNAs and translation. Here the authors identify a mutation in the Elp6 gene that contributes to the cerebellar ataxia-like phenotype in a mutant mouse.

    • Marija Kojic
    • Monika Gaik
    • Brandon J. Wainwright
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-13