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Showing 1–6 of 6 results
Advanced filters: Author: Sergi Regot Clear advanced filters

  • For synthetic biologists' creativity to be unleashed, basic circuits must become truly interchangeable, that is, modular and scalable. This study, one of two linked papers, has harnessed yeast pheromone communication to achieve complex computation through communication between individual cells performing simple logic functions. Such extracellular 'chemical wiring' is one promising way to get around intracellular noise when building more complex genetic circuitry.

    • Sergi Regot
    • Javier Macia
    • Ricard Solé
    Research
    Nature
    Volume: 469, P: 207-211

  • Discrepancies between model prediction and experimental measurements enable molecular-level discovery with a whole-cell model of Mycoplasma genitalium.

    • Jayodita C Sanghvi
    • Sergi Regot
    • Markus W Covert
    Research
    Nature Methods
    Volume: 10, P: 1192-1195

  • Natural selection may favor traits underlying aging-related diseases if they benefit the young. Wang et al. find that oxidative activation of CaMKII provides physiological benefits critical to the initial and continued success of vertebrates but at the cost of disease, frailty, and shortened lifespan.

    • Qinchuan Wang
    • Erick O. Hernández-Ochoa
    • Mark E. Anderson
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-17