Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–4 of 4 results
Advanced filters: Author: Sergio Espeso-Gil Clear advanced filters

  • The authors develop a supervised and unsupervised learning algorithm Signature. Machine learning and network model analysis of Hi-C datasets across 62 2n genomes suggest that inter-chromosomal contacts demarcate genome topology along a spatial gradient of genome activity.

    • Milad Mokhtaridoost
    • Jordan J. Chalmers
    • Philipp G. Maass
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Repeat-rich sequences play a role in 3D genome architecture in higher eukaryotes; however, this remains unexplored in brain cells. Here, the authors show that upregulation of endogenous retroviral (ERV) sequences is linked to changes in the 3D structure in the brain, which is also observed by comparison of mouse strains with recent retrotransposon expansion.

    • Sandhya Chandrasekaran
    • Sergio Espeso-Gil
    • Schahram Akbarian
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-16

  • Although many neuropsychiatric risk genes are known to contribute to epigenetic regulation of gene expression, very little is known about specific chromatin-associated mechanisms that govern the formation and maintenance of neuronal connectivity. Here, the authors report that transcallosal connectivity is critically dependent on C11orf46/ARL14EP, a nuclear protein encoded in the chromosome 11p13 WAGR risk locus, and that RNA-guided epigenetic editing of hyperexpressed Sema6a gene promoters in C11orf46-knockdown neurons resulted in normalization of expression and rescue of transcallosal dysconnectivity via repressive chromatin remodeling.

    • Cyril J. Peter
    • Atsushi Saito
    • Atsushi Kamiya
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-14

  • Promoter–enhancer loopings and other features of the 3D genome are dynamically regulated in the brain. In this Review, Akbarian and colleagues discuss how neuronal and glial gene expression is governed by the 3D genome, with implications for cognition and neuropsychiatric disease.

    • Prashanth Rajarajan
    • Sergio Espeso Gil
    • Schahram Akbarian
    Reviews
    Nature Reviews Neuroscience
    Volume: 17, P: 681-691