Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease and atherosclerosis. In this Review, Kon and colleagues discuss CKD-induced atherosclerosis, with a particular focus on the experimental and clinical findings that support a key role for macrophages in atherogenesis. The authors describe how CKD can affect macrophage accumulation and function, including the roles of lipid, lipoprotein handling and angiotensin II in these processes.
- Valentina Kon
- MacRae F. Linton
- Sergio Fazio
