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Showing 1–2 of 2 results
Advanced filters: Author: Sergio I. Valdes-Ferrer Clear advanced filters

  • Coagulation factor VIII deficiency in hemophilia A disrupts clotting and prolongs bleeding. Here, the authors show that vagus nerve stimulation bypasses this defect and improves hemostasis in hemophilia A mice through a mechanism requiring acetylcholine-secreting ChAT+ T lymphocytes in spleen and α7nAChR on circulating platelets.

    • Carlos E. Bravo-Iñiguez
    • Jason R. Fritz
    • Jared M. Huston
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-12

  • Double-stranded RNA-dependent protein kinase (PKR) is shown to be a key regulator of the inflammasome; PKR is central for caspase-1 activation and the release of interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1) in response to a diverse range of stimuli.

    • Ben Lu
    • Takahisa Nakamura
    • Kevin J. Tracey
    Research
    Nature
    Volume: 488, P: 670-674