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Showing 1–11 of 11 results
Advanced filters: Author: Sergiu P. Paşca Clear advanced filters

  • Human pluripotent stem cells were used to develop dorsal and ventral forebrain 3D spheroids, which can be assembled to study interneuron migration and to derive a functionally integrated forebrain system with cortical interneurons and glutamatergic neurons.

    • Fikri Birey
    • Jimena Andersen
    • Sergiu P. Paşca
    Research
    Nature
    Volume: 545, P: 54-59

  • Timothy syndrome is a neurodevelopmental disease that includes autism-like features. Using iPS-derived neurons from individuals with Timothy syndrome, Ricardo Dolmetsch and his colleagues identify changes in cortical neuron fate and neurotransmitter expression that may begin to explain the neural mechanisms that underlie this disorder.

    • Sergiu P Paşca
    • Thomas Portmann
    • Ricardo E Dolmetsch
    Research
    Nature Medicine
    Volume: 17, P: 1657-1662

  • Human pluripotent stem cell-derived in vitro models have potential as tools to study aspects of human brain development. Here, Heilshorn and colleagues review biomaterial-based approaches that may be integrated into these models in an effort to develop them further and better recapitulate neurodevelopmental processes.

    • Julien G. Roth
    • Michelle S. Huang
    • Sarah C. Heilshorn
    Reviews
    Nature Reviews Neuroscience
    Volume: 22, P: 593-615

  • The authors report that calcium channels with a mutation associated with Timothy syndrome cause activity-dependent dendrite retraction in rodent neurons and in induced pluripotent stem cell–derived neurons from individuals with Timothy syndrome. This retraction was independent of Ca permeation but was associated with activation of RhoA signaling.

    • Jocelyn F Krey
    • Sergiu P Paşca
    • Ricardo E Dolmetsch
    Research
    Nature Neuroscience
    Volume: 16, P: 201-209

  • Zika virus infection is associated with birth defects, including microcephaly, but also with disorders of peripheral nerves. Oh et al. use rodent and human cell models to explore how the virus affects the peripheral nervous system.

    • Themasap A. Khan
    • Sergiu P. Paşca
    News & Views
    Nature Neuroscience
    Volume: 20, P: 1191-1192

  • Stem cell–derived human motor neurons were used to investigate the cellular mechanisms underlying C9ORF72-related amyotrophic lateral sclerosis.

    • Rebecca M Marton
    • Sergiu P Paşca
    News & Views
    Nature Medicine
    Volume: 24, P: 256-257

  • Organoids are 3D cell culture systems that mimic the structural and functional characteristics of organs. In this Review, the authors discuss the biochemical and mechanical material properties relevant for organoid formation and highlight materials designed with the aim to establish organoid cultures as powerful research platforms.

    • Michael J. Kratochvil
    • Alexis J. Seymour
    • Sarah C. Heilshorn
    Reviews
    Nature Reviews Materials
    Volume: 4, P: 606-622