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Showing 1–9 of 9 results
Advanced filters: Author: Seth B. Herzon Clear advanced filters

  • The bacterial genotoxin colibactin induces DNA interstrand cross-links which pose a barrier to DNA replication. Here, the authors use Xenopus egg extracts to show that the Fanconi anemia pathway is responsible for repairing these cross-links.

    • Maria Altshuller
    • Xu He
    • Daniel R. Semlow
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-21

  • (−)-Lomaiviticin A inhibits the growth of cancer cells at nanomolar to picomolar concentrations; however, the basis for this potent cytotoxicity is not known. This natural product has now been shown to induce production of DNA double-strand breaks at nanomolar concentrations. Evidence demonstrates that strand cleavage proceeds via reactive carbon-centred free radical intermediates.

    • Laureen C. Colis
    • Christina M. Woo
    • Seth B. Herzon
    Research
    Nature Chemistry
    Volume: 6, P: 504-510

  • General synthetic methods to access pleuromutilin antibiotics are limited due to their complex carbocyclic skeleton. Now, a synthetic platform has been developed to access structurally diverse pleuromutilins with variations at the quaternary C12 position and hydrindanone cores. Seventeen structurally distinct derivatives were prepared and evaluated against a panel of Gram-positive and -negative bacteria.

    • Olivia Goethe
    • Mikaela DiBello
    • Seth B. Herzon
    Research
    Nature Chemistry
    Volume: 14, P: 1270-1277

  • Precolibactin 886 is a complex microbiome-derived metabolite implicated in colorectal cancer and produced by the clb gene cluster. A chemical synthesis and analysis of precolibactin 886 is reported which shows that its biosynthetic precursor degrades to other known clb metabolites. The data also provide insights into the structures and reactivity of advanced clb products.

    • Alan R. Healy
    • Kevin M. Wernke
    • Seth B. Herzon
    Research
    Nature Chemistry
    Volume: 11, P: 890-898

  • Multifunctional catalysts typically process substrates and intermediates concurrently. Here, a strategy is described to separate catalytic activities in the time domain (temporal separation). Application of this strategy has led to the development of a method to effect the anti-Markovnikov reductive functionalization of terminal alkynes; such an approach may facilitate the development of other synthetic reaction cascades.

    • Le Li
    • Seth B. Herzon
    Research
    Nature Chemistry
    Volume: 6, P: 22-27