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Showing 1–4 of 4 results

Advanced filters: Author: Seth H. Cassel Clear advanced filters

A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

Michel et al. report unique localization of non-canonical BAF to CTCF sites and promoters, which confers synthetic lethality in canonical BAF-perturbed synovial sarcoma and malignant rhabdoid tumour cells.

Brittany C. Michel
Andrew R. D’Avino
Cigall Kadoch
Research05 Nov 2018
Nature Cell Biology

Volume: 20, P: 1410-1420
ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair

Klim et al. illuminate pathomechanisms of ALS using pluripotent stem cells to identify transcripts altered in human motor neurons by perturbations to ALS protein TDP-43, finding the microtubule regulator STMN2 highly sensitive to TDP-43 malfunctions.

Joseph R. Klim
Luis A. Williams
Kevin Eggan
Research14 Jan 2019
Nature Neuroscience

Volume: 22, P: 167-179
Wiskott–Aldrich syndrome protein (WASP) is a tumor suppressor in T cell lymphoma

WASP is a novel tumor-suppressor gene in ALK-driven anaplastic large cell lymphoma through modulation of CDC42 and MAPK signaling and provides a rationale for combination therapy.

Matteo Menotti
Chiara Ambrogio
Roberto Chiarle
Research03 Dec 2018
Nature Medicine

Volume: 25, P: 130-140
SMARCB1 is required for widespread BAF complex–mediated activation of enhancers and bivalent promoters

Loss of BAF47 destabilizes the BAF complex on chromatin, and reintroduction of BAF47 leads to enhancer activation and Polycomb opposition at bivalent promoters. BAF47 loss affects BAF and PBAF complexes, which have distinct functions in regulation of enhancers and promoters.

Robert T Nakayama
John L Pulice
Cigall Kadoch
Research25 Sept 2017
Nature Genetics

Volume: 49, P: 1613-1623