Nature Search

Human infections with highly pathogenic avian influenza A(H5N1) viruses in the United States from March 2024 to May 2025

In an updated report on 70 laboratory-confirmed highly pathogenic avian influenza A H5N1 cases in the USA between March 2024 and May 2025, the absence of human-to-human transmission to date was confirmed, with no known mutations of resistance to neuroaminidase inhibitors.

Melissa A. Rolfes
Krista Kniss
Sonja J. Olsen
Research25 Jul 2025
Nature Medicine

Volume: 31, P: 3889-3898
An RNA aptamer that shifts the reduction potential of metabolic cofactors

An RNA aptamer that selectively binds FAD over FADH₂ shifted the reduction potential of the bound cofactor, similar to flavoproteins, and was shown through structural characterization to use π–π and donor–π interactions to drive the shift.

John S. Samuelian
Thomas J. Gremminger
Dana A. Baum
ResearchOpen Access12 Sept 2022
Nature Chemical Biology

Volume: 18, P: 1263-1269
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants

Multiple variants of SARS-CoV-2 are inhibited by a trispecific DARPin.

Sylvia Rothenberger
Daniel L. Hurdiss
Jakob Trimpert
ResearchOpen Access21 Jul 2022
Nature Biotechnology

Volume: 40, P: 1845-1854
Effects of tirzepatide on circulatory overload and end-organ damage in heart failure with preserved ejection fraction and obesity: a secondary analysis of the SUMMIT trial

In a mechanistic analysis of the SUMMIT trial that tested tirzepatide in patients with heart failure with preserved ejection fraction and obesity, treatment with this dual glucagon-like peptide-1 receptor and gastric inhibitory polypeptide agonist, as compared with placebo, reduced blood pressure and estimated circulatory volume–pressure overload, reduced systemic inflammation and mitigated cardiovascular and kidney injury.

Barry A. Borlaug
Michael R. Zile
Milton Packer
ResearchOpen Access17 Nov 2024
Nature Medicine

Volume: 31, P: 544-551
Evinacumab in severe hypertriglyceridemia with or without lipoprotein lipase pathway mutations: a phase 2 randomized trial

The potential of evinacumab, a monoclonal antibody targeting angiopoietin-like 3, for reducing triglyceride levels was tested in patients with severe hypertriglyceridemia due to differing genetic etiologies.

Robert S. Rosenson
Daniel Gaudet
Daniel J. Rader
ResearchOpen Access06 Mar 2023
Nature Medicine

Volume: 29, P: 729-737
Preclinical development and phase 1 trial of a novel siRNA targeting lipoprotein(a)

A small-interfering RNA targeting lipoprotein(a), which is implicated in coronary artery disease, durably reduces lipoprotein(a) levels in preclinical models and in a phase 1 clinical trial.

Michael J. Koren
Patrick Maurice Moriarty
Gerald F. Watts
Research13 Jan 2022
Nature Medicine

Volume: 28, P: 96-103
Exome sequencing of 20,979 individuals with epilepsy reveals shared and distinct ultra-rare genetic risk across disorder subtypes

In this largest whole-exome sequencing study of epilepsies to date, the Epi25 Collaborative identified extremely rare variants that confer risk for diverse epilepsy subtypes, highlighting roles in synaptic transmission and neuronal excitability.

Siwei Chen
Bassel W. Abou-Khalil
Samuel F. Berkovic
Research03 Oct 2024
Nature Neuroscience

Volume: 27, P: 1864-1879
Genome-wide identification and phenotypic characterization of seizure-associated copy number variations in 741,075 individuals

Here, the authors perform a meta-analysis in 26,699 people with seizures and 492,324 controls to identify 25 genome-wide significant copy-number variants. The discovered loci point to known disease genes and associations with clinical annotations.

Ludovica Montanucci
David Lewis-Smith
Dennis Lal
ResearchOpen Access20 Jul 2023
Nature Communications

Volume: 14, P: 1-19
A communal catalogue reveals Earth’s multiscale microbial diversity

As phase 1 of the Earth Microbiome Project, analysis of 16S ribosomal RNA sequences from more than 27,000 environmental samples delivers a global picture of the basic structure and drivers of microbial distribution.

Luke R. Thompson
Jon G. Sanders
Hongxia Zhao
ResearchOpen Access01 Nov 2017
Nature

Volume: 551, P: 457-463

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