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Showing 1–3 of 3 results
Advanced filters: Author: Seung-Joo Yang Clear advanced filters
  • Single-stranded DNA-binding proteins protect exposed DNA during replication but create potential barriers for polymerases. Here, the authors reveal that DNA polymerase actively and sequentially displaces stationary SSB proteins. The SSB C-terminal tail facilitates this process by reducing energy barriers for displacement to ensure DNA replication.

    • Longfu Xu
    • Shikai Jin
    • Gijs J. L. Wuite
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-16
  • Calcium flux must be carefully controlled during the phagocytosis of apoptotic cells (efferocytosis), although how this occurs is not fully understood. Here, the authors show that the Cereblon E3 ligase regulates Orai1 degradation and subsequently SOCE-mediated calcium influx.

    • Hyunji Moon
    • Chanhyuk Min
    • Daeho Park
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-13
  • Macromolecular crowding significantly affects interactions between macromolecules such as proteins, DNA and RNA. Akabayov and colleagues use a SAXS reconstitution assay to show that the effect of macromolecular crowding on T7 DNA replication causes structural changes of the replisome.

    • Barak Akabayov
    • Sabine R. Akabayov
    • Charles C. Richardson
    Research
    Nature Communications
    Volume: 4, P: 1-10