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Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion

Tai Young Kim
Sangeun Jeon
C. Justin Lee
ResearchOpen Access25 May 2021
Experimental & Molecular Medicine

Volume: 53, P: 956-972
An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation

Repeat vaccination with COVID-19 mRNA vaccines has been shown to increase breadth of the antibody response. Here the authors demonstrate that B cell clones induced by the ancestral COVID-19 vaccine develop into daughter clones with different reactivity to individual SARS-CoV-2 variants through the accumulation of somatic hypermutations.

Seoryeong Park
Jaewon Choi
Junho Chung
ResearchOpen Access20 Apr 2024
Nature Communications

Volume: 15, P: 1-9
Effect of S267F variant of NTCP on the patients with chronic hepatitis B

Hye Won Lee
Hye Jung Park
Sang Hoon Ahn
ResearchOpen Access15 Dec 2017
Scientific Reports

Volume: 7, P: 1-7
Quasi-equilibrium phase coexistence in single component supercritical fluids

In their supercritical state simple fluids are generally thought to assume a homogeneous phase throughout. Lee et al. find that liquid droplets temporarily formed in a supercritical background after sub-critical injection can survive for a surprisingly long time.

Seungtaek Lee
Juho Lee
Gunsu Yun
ResearchOpen Access30 Jul 2021
Nature Communications

Volume: 12, P: 1-7
Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation

Stanley Lemon and colleagues show that the HCV replicase is sensitive to lipid peroxidation, which may restrict viral replication in vitro and in vivo.

Daisuke Yamane
David R McGivern
Stanley M Lemon
Research27 Jul 2014
Nature Medicine

Volume: 20, P: 927-935
Construction and validation of a cell based reporter assay for identifying inhibitors of SARS coronavirus 2 RNA dependent RNA polymerase activity

Eunjeong Kang
Haelim Yoon
Sayeon Cho
ResearchOpen Access26 May 2025
Scientific Reports

Volume: 15, P: 1-14
Angiotensin receptor blockers, but not angiotensin-converting enzyme inhibitors, inhibit abnormal bone changes in spondyloarthritis

Jin Sun Choi
Ji-Young Kim
Seung Cheol Shim
ResearchOpen Access01 Nov 2023
Experimental & Molecular Medicine

Volume: 55, P: 2346-2356
Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses

Here, Honegger et al. study two HCV-infected women through two consecutive pregnancies and chronicle T cell escape mutations in viral proteins that revert during pregnancy and reappear postpartum. The findings highlight the dynamic between T cell–mediated pressure and viral fitness, with implications for vertical transmission of HCV.

Jonathan R Honegger
Seungtaek Kim
Christopher M Walker
Research27 Oct 2013
Nature Medicine

Volume: 19, P: 1529-1533
Ankyrin Repeat Domain 1 is Up-regulated During Hepatitis C Virus Infection and Regulates Hepatitis C Virus Entry

Thoa T. Than
Giao V. Q. Tran
Soon B. Hwang
ResearchOpen Access10 Feb 2016
Scientific Reports

Volume: 6, P: 1-14

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Platycodin D, a natural component of Platycodon grandiflorum, prevents both lysosome- and TMPRSS2-driven SARS-CoV-2 infection by hindering membrane fusion

An ancestral SARS-CoV-2 vaccine induces anti-Omicron variants antibodies by hypermutation

Effect of S267F variant of NTCP on the patients with chronic hepatitis B

Quasi-equilibrium phase coexistence in single component supercritical fluids

Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation

Construction and validation of a cell based reporter assay for identifying inhibitors of SARS coronavirus 2 RNA dependent RNA polymerase activity

Angiotensin receptor blockers, but not angiotensin-converting enzyme inhibitors, inhibit abnormal bone changes in spondyloarthritis

Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses

Ankyrin Repeat Domain 1 is Up-regulated During Hepatitis C Virus Infection and Regulates Hepatitis C Virus Entry

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