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Showing 1–4 of 4 results
Advanced filters: Author: Severin Mühleder Clear advanced filters

  • Fernández-Chacón et al. use imaging and scRNA-seq after targeting multiple Notch genes and angiogenic signaling pathways to find that the function of these pathways in vascular pathophysiology cannot be predicted by assessing transcriptional states.

    • Macarena Fernández-Chacón
    • Severin Mühleder
    • Rui Benedito
    ResearchOpen Access
    Nature Cardiovascular Research
    Volume: 2, P: 530-549

  • How lymphatic vessels arise from veins is still poorly understood. A study reports the discovery of a ribosome biogenesis regulator Ddx21 as a previously unappreciated specific factor that is important for the first steps of lymphatic but not blood vessel development. The finding may lead to better strategies to selectively target lymphangiogenesis.

    • Severin Mühleder
    • Rui Benedito
    News & Views
    Nature Cell Biology
    Volume: 23, P: 1109-1110

  • Arterial development relies on the timely and MYC-dependent suppression of endothelial metabolism and the cell cycle in pre-arterial endothelial cells through Notch signalling.

    • Wen Luo
    • Irene Garcia-Gonzalez
    • Rui Benedito
    Research
    Nature
    Volume: 589, P: 437-441