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A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice

Konturek-Ciesla et al show that low intensity conditioning with antibody mediated haematopoietic stem cell (HSC) depletion coupled to HSC transplantation boosts blood cell and immune cell generation in aging mice, slowing disease. This approach may help treat age-related blood disorders in humans.

Anna Konturek-Ciesla
Qinyu Zhang
David Bryder
ResearchOpen Access02 Jun 2025
Nature Communications

Volume: 16, P: 1-13
Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state

Ariana S. Calderón
Roshanak Ghazanfari
Charlotta Böiers
ResearchOpen Access11 Jul 2025
Leukemia

Volume: 39, P: 2099-2111
TSLP-mediated fetal B lymphopoiesis?

Christina T Jensen
Shabnam Kharazi
Sten Eirik W Jacobsen
Correspondence01 Sept 2007
Nature Immunology

Volume: 8, P: 897
DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

Frank Rosenbauer and colleagues show that alternative functional programs of hematopoietic stem cells are governed by gradual differences in the cellular DNA methylation level.

Ann-Marie Bröske
Lena Vockentanz
Frank Rosenbauer
Research04 Oct 2009
Nature Genetics

Volume: 41, P: 1207-1215
Implications of stress-induced gene expression for hematopoietic stem cell aging studies

This study reveals that many previously reported changes in gene expression in aging hematopoietic stem cells (HSCs) may be linked to extraction stress rather than aging itself and has implications for future HSC aging research.

Anna Konturek-Ciesla
Rasmus Olofzon
David Bryder
ResearchOpen Access16 Jan 2024
Nature Aging

Volume: 4, P: 177-184
Ontogeny shapes the ability of ETV6::RUNX1 to enhance hematopoietic stem cell self-renewal and disrupt early lymphopoiesis

Mohamed Eldeeb
Anna Konturek-Ciesla
David Bryder
CorrespondenceOpen Access19 Jan 2024
Leukemia

Volume: 38, P: 455-459
The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation

Yaser Heshmati
Shabnam Kharazi
Julian Walfridsson
ResearchOpen Access25 Jul 2018
Scientific Reports

Volume: 8, P: 1-17

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A non-genotoxic stem cell therapy boosts lymphopoiesis and averts age-related blood diseases in mice

Ontogeny-specific induction of the KMT2A::AFF1-fusion drives development of a distinct CD24 positive pre-leukemic state

TSLP-mediated fetal B lymphopoiesis?

DNA methylation protects hematopoietic stem cell multipotency from myeloerythroid restriction

Implications of stress-induced gene expression for hematopoietic stem cell aging studies

Ontogeny shapes the ability of ETV6::RUNX1 to enhance hematopoietic stem cell self-renewal and disrupt early lymphopoiesis

The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation

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