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Showing 1–4 of 4 results
Advanced filters: Author: Shady Younis Clear advanced filters

  • The immune mechanisms underlying synovitis and joint tissue destruction in rheumatoid arthritis (RA) remain incompletely defined. Here, the authors demonstrate that ACPA+ RA patients have activated clonally expanded cytotoxic GZMB+ CD8+ T cells in blood and synovium that target and are activated by citrullinated antigens to mediate cell killing.

    • Jae-Seung Moon
    • Shady Younis
    • William H. Robinson
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-15

  • Epstein–Barr virus (EBV) infection is associated with numerous autoimmune diseases, including rheumatic diseases. In this Review, Robinson and colleagues provide an overview of the biology of EBV, the potential mechanisms through which EBV could promote autoimmune diseases and how EBV might be targeted for the treatment of autoimmune disease.

    • William H. Robinson
    • Shady Younis
    • Tobias V. Lanz
    Reviews
    Nature Reviews Rheumatology
    Volume: 20, P: 729-740

  • Junfeng Chen et al. examine potential functional consequences of reproduction timing-associated TSHR alleles segregating in Atlantic herring. By comparing fish that spawn during the spring to those that spawn in the autumn, they find that the spring-allele is correlated with enhanced cAMP signaling and that both coding and non-coding variants in the TSHR locus contribute to seasonal reproduction.

    • Junfeng Chen
    • Huijuan Bi
    • Leif Andersson
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-13