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Showing 1–4 of 4 results
Advanced filters: Author: Shae Padrick Clear advanced filters

  • In cells, WAVE protein, a central regulator of actin dynamics during cell motility, is constitutively incorporated into WAVE regulatory complex (WRC), is normally present in an inactive state and can be activated by a number of inputs. These authors present the structure and mechanistic analysis of WRC. The combined data reveal how the WAVE protein is inhibited within the WRC complex and provide mechanisms for WRC activation at the plasma membrane.

    • Zhucheng Chen
    • Dominika Borek
    • Michael K. Rosen
    Research
    Nature
    Volume: 468, P: 533-538

  • WAVE proteins in the WASP family are controlled by incorporation into the WAVE regulatory complex (WRC), which transmits information from the Rac GTPase to the actin cytoskeleton. By reconstituting human and fly WRCs, the native complex is shown to be inactive. Rac activates the WRC, but does not cause subunit dissociation. These results reconcile previous work and reveal common regulatory principles for the WASP family.

    • Ayman M Ismail
    • Shae B Padrick
    • Michael K Rosen
    Research
    Nature Structural & Molecular Biology
    Volume: 16, P: 561-563

  • Abp1, a type II actin nucleation promoting factor, is a known component of branched actin networks but its mechanism remains poorly understood. Here, the authors find that Abp1 enhances Arp2/3-mediated actin branch formation, and blocks ‘debranching’ by GMF, making it a pro-branching factor.

    • Siyang Guo
    • Olga S. Sokolova
    • Bruce L. Goode
    ResearchOpen Access
    Nature Communications
    Volume: 9, P: 1-14

  • A forward-genetic screen revealed that the mutations in DNA polymerase α (POLA1) are resistant to the effects of CD437. The direct interaction of CD437 and POLA1 blocks DNA replication and promotes cancer cell death.

    • Ting Han
    • Maria Goralski
    • Deepak Nijhawan
    Research
    Nature Chemical Biology
    Volume: 12, P: 511-515