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Showing 1–11 of 11 results
Advanced filters: Author: Shahriar Mobashery Clear advanced filters

  • SPOR domains are present in bacterial proteins that recognize cell-wall peptidoglycan strands stripped of the peptide stems. Here, Alcorlo et al. show that, indeed, the presence of peptide stems abrogates binding to a SPOR domain, and provide insights into the molecular basis for recognition.

    • Martín Alcorlo
    • David A. Dik
    • Juan A. Hermoso
    ResearchOpen Access
    Nature Communications
    Volume: 10, P: 1-13

  • Peptidoglycans (PG) define bacterial cell shapes. Here, the authors provide mechanistic insights into the peptidoglycan peptidase 3 (Pgp3) from the spiral shaped human pathogen Campylobacter jejuni by determining its crystal structure alone and in complex with synthetic cell-wall PG derivatives, and they further show that the enzyme has both d,d-endopeptidase and d,d-carboxypeptidase activities

    • Kyungjin Min
    • Doo Ri An
    • Hyung Ho Lee
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-11

  • The increasing levels of antibiotic resistance observed in clinical isolates, coupled with a lack of new drugs coming through the development pipeline, make the problem of antibiotic resistance a global crisis. In this Essay, Davies and colleagues draw up a priority list of urgent steps and future research directions that are needed to tackle this growing problem.

    • Karen Bush
    • Patrice Courvalin
    • Helen I. Zgurskaya
    Comments & Opinion
    Nature Reviews Microbiology
    Volume: 9, P: 894-896

  • The structure of an antibiotic that is effective against Gram-positive bacteria, but not against Gram-negative bacteria, has now been modified to improve its effectiveness against Gram-negative bacteria. The approach could help broaden the spectrum of activity of other antibiotics.

    • Jed F. Fisher
    • Shahriar Mobashery
    News & Views
    Nature Chemistry
    Volume: 10, P: 998-1000

  • Streptococcus pneumoniae develop a state of genetic competence, in which the bacteria can acquire exogenous DNA; the competent bacteria also secrete enzymes that trigger the lysis of neighboring non-competent cells. Now the structure of pneumococcal autolysin LytC provides insight into its role in cell wall metabolism and fratricide.

    • Inmaculada Pérez-Dorado
    • Ana González
    • Juan A Hermoso
    Research
    Nature Structural & Molecular Biology
    Volume: 17, P: 576-581

  • Triple combinations of carbapenem, penicillin and β-lactamase inhibitor antibiotic classes are synergistic against MRSA through a mechanism involving allostery-based synergy and collateral sensitivity and can thus be applied at doses that lead to less resistance.

    • Patrick R Gonzales
    • Mitchell W Pesesky
    • Gautam Dantas
    Research
    Nature Chemical Biology
    Volume: 11, P: 855-861

  • Peptidoglycan hydrolase 3 (Pgp3) inhibitors are designed that can change the helical morphology of Campylobacter jejuni to rod-shaped and decrease its virulence.

    • Yuri Choi
    • Ji Su Park
    • Hyung Ho Lee
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-10