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Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter

This study profiles the spatial transcriptomic landscape of mouse brain coronal sections across three age groups and both sexes. Here, authors show a strong female-biased pro-inflammatory gene signature in white matter fiber tracts.

Lin Wang
Chang-Yi Cui
Payel Sen
ResearchOpen Access04 Apr 2025
Nature Communications

Volume: 16, P: 1-21

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Spatial transcriptomics of the aging mouse brain reveals origins of inflammation in the white matter

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