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Showing 1–7 of 7 results
Advanced filters: Author: Shalender Bhasin Clear advanced filters
  • Mauvais-Jarvis and Bhasin provide an in-depth review of testosterone’s role in maintaining cardiometabolic health, musculoskeletal integrity and energy balance, drawing on evidence from testosterone replacement therapy in humans and mechanistic research in rodent models.

    • Franck Mauvais-Jarvis
    • Shalender Bhasin
    Reviews
    Nature Metabolism
    Volume: 8, P: 52-61
  • The predictive value of blood levels of GDF11/8 proteins in humans for future disease outcomes has been unclear. Here, the authors show that low levels of specific activated GDF11/8 subforms are strongly associated with future cardiovascular events, mortality, and dementia risk.

    • Ryan G. Walker
    • Tomohiro Kato
    • Richard T. Lee
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-14
  • In men with classic hypogonadism, testosterone therapy induces a number of beneficial effects. However, in older men with age-related decline in testosterone levels, the clinical benefits and long-term risks of testosterone therapy have not been adequately assessed in large, randomized clinical trials. This Review discusses potential benefits and risks of testosterone therapy in these individuals in the context of incomplete evidence on safety and efficacy.

    • Matthew Spitzer
    • Grace Huang
    • Shalender Bhasin
    Reviews
    Nature Reviews Endocrinology
    Volume: 9, P: 414-424
  • Testosterone use as anabolic therapy is controversial. Here, meta-analyses show that testosterone increases skeletal muscle mass and strength in androgen-deficient young men, older men and men with chronic illness; these data provide a compelling rationale for the development of selective androgen receptor modulators that mimic testosterone's effects without its side effects.

    • Shalender Bhasin
    • Olga M Calof
    • James T Dalton
    Reviews
    Nature Clinical Practice Endocrinology & Metabolism
    Volume: 2, P: 146-159