PGC-1α is activated by exercise and promotes resistance to fatigue in muscles. Here, the authors show that PGC-1α activates the malate-aspartate shuttle, and allows muscle to utilise kynurenine, leading to more efficient glucose oxidation and mitochondrial respiration.
- Leandro Z. Agudelo
- Duarte M. S. Ferreira
- Jorge L. Ruas
