Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–5 of 5 results
Advanced filters: Author: Shan-hui Hsu Clear advanced filters

  • Novel chitosan–celluose nanofiber (CS–CNF) composite hydrogels (modulus ~2 kPa) were prepared to have tunable self-healing properties. The injectability and self-healing ability were significantly enhanced for composite hydrogels. The optimized hydrogel promoted the proliferation and differentiation of neural stem cells in vitro as well as functional recovery (50% enhancement over pristine CS hydrogel) in brain-injured zebrafish. Self-healing properties of CS–CNF hydrogels were positively correlated with regenerative capacities and oxygen metabolism of the hydrogels. A mechanism of multiple-bond interactions may explain the biphasic change of self-healing for these hydrogels. The findings provide some design rationale for self-healing hydrogels with potential biomedical applications.

    • Kun-Chih Cheng
    • Chih-Feng Huang
    • Shan-hui Hsu
    ResearchOpen Access
    NPG Asia Materials
    Volume: 11, P: 1-17

  • A novel chitosan–fibrin (CF) injectable, self-healing hydrogel (modulus ~1.2 kPa) is developed. The CF hydrogel has excellent self-healing properties and induces vascular endothelial cells to form capillary-like structure. The self-healing and angiogenic capacities are associated with the interpenetrating network structure of the hydrogel. The hydrogel degrades ~70% in 2 weeks. Injection of the CF hydrogel alone can promote angiogenesis in the perivitelline space of zebrafish and rescue the blood circulation in ischemic hindlimbs of mice. This biomimetic hydrogel has potential applications in vascular repair.

    • Fu-Yu Hsieh
    • Lei Tao
    • Shan-hui Hsu
    ResearchOpen Access
    NPG Asia Materials
    Volume: 9, P: e363

  • A nanosheet structure on a glass plate can transfer naked DNA into difficult-to-transfect cells (for example, stem cells) in limited time after contact (‘transfection window’) without any vector. The transfected cells express the specific proteins a week later. The gene uptake and expression are associated with the cytoskeleton arrangement on the silica nanosheets by activating the cell-membrane integrin receptor.

    • Nien-Chi Huang
    • Qingmin Ji
    • Shan-hui Hsu
    ResearchOpen Access
    NPG Asia Materials
    Volume: 7, P: e184