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Showing 1–4 of 4 results
Advanced filters: Author: Shane Miersch Clear advanced filters

  • Combinatorial protein engineering based on structural data and the differential expression of alternate second receptor chains for interleukin-4 (IL-4) is used to modify and tune cellular specificity on primary human cells.

    • Shane Miersch
    • Sachdev S Sidhu
    News & Views
    Nature Chemical Biology
    Volume: 8, P: 955-956

  • The antigenic landscape of α-HCoVs S proteins is revealed, highlighting the challenges faced by pan-HCoV vaccine design but also revealing opportunities for development of broadly effective vaccines against a subset of HCoVs.

    • Jiangchao Xiang
    • Jie Su
    • Bei Yang
    ResearchOpen Access
    Communications Biology
    Volume: 5, P: 1-13

  • Suryamohan, Diwanji, Stawiski et al. identify natural ACE2 variants that are predicted to alter virus–host interactions. They find that soluble ACE2 K26R and T92I variants are more effective in blocking the entry of SARS-CoV-2 S-protein pseudotyped virus, compared to wild-type ACE2. This study suggests that ACE2 variants may modulate the host susceptibility to SARS-CoV-2.

    • Kushal Suryamohan
    • Devan Diwanji
    • Somasekar Seshagiri
    ResearchOpen Access
    Communications Biology
    Volume: 4, P: 1-11