Advanced search

Filter By:

Journal Check one or more journals to show results from those journals only.

Choose more journals

Article type Check one or more article types to show results from those article types only.
Subject Check one or more subjects to show results from those subjects only.
Date Choose a date option to show results from those dates only.

Custom date range

Clear all filters
Sort by:
Showing 1–13 of 13 results
Advanced filters: Author: Shangyu Dang Clear advanced filters

  • Using two synaptic proteins as examples, Chen et al. reveal that phase-separation-mediated formation of molecular condensates can change the biomolecular interaction specificities; the network complexity in the condensates can have a stronger impact than affinity on the subcellular localization of proteins.

    • Yan Chen
    • Chenxue Ma
    • Mingjie Zhang
    Research
    Nature Chemical Biology
    Volume: 22, P: 58-68

  • Presenilin, the catalytic component of γ-secretase, cleaves amyloid precursor protein into short peptides that form the plaques that are found in the brains of patients with Alzheimer’s disease; here the structure of a presenilin homologue is described, which will serve as a framework for understanding the mechanisms of action of presenilin and γ-secretase.

    • Xiaochun Li
    • Shangyu Dang
    • Yigong Shi
    Research
    Nature
    Volume: 493, P: 56-61

  • TMEM63s are mechanosensitive ion channels activated by hypo-osmolality. Here, the authors determine the cryo-EM structure of mouse TMEM63C confirming its predominant monomeric state and the significance of TM0-TM6 coupling in channel activity.

    • Yuqi Qin
    • Daqi Yu
    • Shangyu Dang
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-10

  • In Escherichia coli, the uptake of L-fucose, an important source of carbon for microorganisms, is mediated by a proton symporter from the major facilitator superfamily (MFS). These authors report the first X-ray crystal structure of the outward-open conformation of an MFS proton transporter, FucP. Building on previous work, they develop a working model for how the substrate is recognized by the transporter and how the protein mediates L-fucose/proton symport.

    • Shangyu Dang
    • Linfeng Sun
    • Nieng Yan
    Research
    Nature
    Volume: 467, P: 734-738

  • Structures of the yeast replisome associated with the FACT complex and an evicted histone hexamer offer insights into the mechanism of replication-coupled histone recycling for maintaining epigenetic inheritance.

    • Ningning Li
    • Yuan Gao
    • Yuanliang Zhai
    Research
    Nature
    Volume: 627, P: 890-897

  • SARS-CoV-2 variants of concern such as the Omicron variant pose a challenge for vaccination and antibody immunotherapy. Here, Zhou et al. isolate a broadly neutralizing antibody (bNAb), named ZCB11, that protects Golden Syrian hamsters against Omicron. Applying CryoEM the authors show that ZCB11 heavy chain predominantly interacts with RBD in up confirmation, which interferes with ACE2 receptor binding.

    • Biao Zhou
    • Runhong Zhou
    • Zhiwei Chen
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-14

  • The Dbf4-dependent kinase Cdc7 (DDK) is essential for eukaryotic DNA replication. Here, the authors present a series of cryo-EM structures elucidating the versatility of this kinase in exerting an ordered phosphorylation of its essential target to promote replication initiation.

    • Jiaxuan Cheng
    • Ningning Li
    • Yuanliang Zhai
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • Coordinating the activities of replicative helicase and DNA polymerase(s) is crucial for DNA replication. Here, the authors show that DNA translocation by CMG is synchronized with the activities of Polε in the leading-strand replisome.

    • Zhichun Xu
    • Jianrong Feng
    • Yuanliang Zhai
    ResearchOpen Access
    Nature Communications
    Volume: 14, P: 1-16