This study demonstrates that ablation of the l-histidine decarboxylase /histamine axis using a genetically modified mouse model ameliorates liver damage and hepatic fibrosis. Further, histamine reactivates the axis via H1/H2 receptors, thus recapitulating the liver damage and fibrosis of primary sclerosing cholangitis. Histamine regulation of TGF-β1 and VEGF-C may be targeted therapies for this disease.
- Lindsey Kennedy
- Vik Meadows
- Heather Francis
