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Showing 1–3 of 3 results
Advanced filters: Author: Shannon M. Lauberth Clear advanced filters

  • Lauberth and Sartorelli consider and discuss recent insights into the biogenesis and function of enhancer RNAs and the key roles they play in the regulation of gene expression.

    • Vittorio Sartorelli
    • Shannon M. Lauberth
    Reviews
    Nature Structural & Molecular Biology
    Volume: 27, P: 521-528

  • Cell-based and in vitro analyses reveal that BRD4 functionally associates with eRNAs and that BRD4 bromodomains, through eRNA interactions, promote BRD4 binding at mutant p53-targeted enhancers to augment enhancer activation and tumor promoting gene expression.

    • Homa Rahnamoun
    • Jihoon Lee
    • Shannon M. Lauberth
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 687-697

  • Inflammation is known to affect cancer development, yet the mechanisms by which immune signaling drives transformation remain unclear. Here, the authors provide evidence that chronic TNF-α signaling promotes the enhancer binding and transcriptional interplay between mutant p53 and NFκB.

    • Homa Rahnamoun
    • Hanbin Lu
    • Shannon M. Lauberth
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-14