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Neurometabolic rewiring in squid (Sepioteuthis lessoniana) optic lobes drives behavioral plasticity and visual integration under environmental acidification

Ocean acidification disrupts squid hunting behavior by inducing neurometabolic rewiring in the optic lobes. Changes in cholinergic transmission and metabolism make predators less successful, showing climate change impacts on marine predator neurobiology.

Garett Joseph Patrick Allen
Jia-Jiun Yan
Yung-Che Tseng
ResearchOpen Access08 Jan 2026
Communications Biology

P: 1-15
Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses

In this study, the authors show that Salmonella enterica serovar Typhimurium co-opts the host mitochondrial citrate carrier (CIC) to regulate the redox state of its vacuole, facilitating intracellular survival.

Chieh-Hua Fu
Yu-Ting Hsu
Shu-Jung Chang
ResearchOpen Access06 Nov 2025
Nature Communications

Volume: 16, P: 1-15
Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype

Chen et al. probe the role of a genotoxin of Salmonella typhi in triggering a senescence-associated secretory phenotype, via mitochondrial DNA damage.

Han-Yi Chen
Wan-Chen Hsieh
Shu-Jung Chang
ResearchOpen Access30 Mar 2024
Nature Communications

Volume: 15, P: 1-17
Skin cells undergo asynthetic fission to expand body surfaces in zebrafish

Terminally differentiated superficial epithelial cells continue dividing in the absence of DNA replication to quickly expand epithelial coverage during rapid growth.

Keat Ying Chan
Ching-Cher Sanders Yan
Chen-Hui Chen
Research27 Apr 2022
Nature

Volume: 605, P: 119-125
Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Human ribonuclease 1 (hRNase 1) regulates innate immunity, hemostasis and RNA clearance. Here, the authors report an alternative function of hRNase 1 as a secretory ligand of Eph receptor EphA4 to enhance breast cancer stemness and promote breast tumour initiation.

Heng-Huan Lee
Ying-Nai Wang
Mien-Chie Hung
ResearchOpen Access13 May 2021
Nature Communications

Volume: 12, P: 1-18
Targeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex

Hung and colleagues show that ALK-mediated CDK9 activation increases homologous recombination repair and PARP inhibition resistance and propose combinatorial inhibition of ALK and PARP as therapeutically beneficial for treatment-resistant tumors.

Yu-Yi Chu
Mei-Kuang Chen
Mien-Chie Hung
ResearchOpen Access17 Oct 2022
Nature Cancer

Volume: 3, P: 1211-1227
Impact of stress-induced hyperglycemia on the outcome of children with trauma: A cross-sectional analysis based on propensity score-matched population

Yi-Wen Tsai
Shao-Chun Wu
Ching-Hua Hsieh
ResearchOpen Access08 Nov 2019
Scientific Reports

Volume: 9, P: 1-6
Efficacy of laryngeal mask airway against postoperative pharyngolaryngeal complications following thyroid surgery: a systematic review and meta-analysis of randomized controlled studies

Kuo-Chuan Hung
Shao-Chun Wu
Cheuk-Kwan Sun
ResearchOpen Access28 Oct 2022
Scientific Reports

Volume: 12, P: 1-12
Low-dose aspirin confers a survival benefit in patients with pathological advanced-stage oral squamous cell carcinoma

Sheng-Dean Luo
Shao-Chun Wu
Chang-Han Chen
ResearchOpen Access25 Aug 2021
Scientific Reports

Volume: 11, P: 1-10
HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors

Chieh-Ting Fang
Hsiao-Hui Kuo
Ling-Huei Yih
ResearchOpen Access01 Sept 2020
Cell Death & Disease

Volume: 11, P: 1-18

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Neurometabolic rewiring in squid (Sepioteuthis lessoniana) optic lobes drives behavioral plasticity and visual integration under environmental acidification

Intracellular Salmonella hijacks the mitochondrial citrate carrier to evade host oxidative defenses

Mitochondrial injury induced by a Salmonella genotoxin triggers the proinflammatory senescence-associated secretory phenotype

Skin cells undergo asynthetic fission to expand body surfaces in zebrafish

Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation

Targeting the ALK–CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex

Impact of stress-induced hyperglycemia on the outcome of children with trauma: A cross-sectional analysis based on propensity score-matched population

Efficacy of laryngeal mask airway against postoperative pharyngolaryngeal complications following thyroid surgery: a systematic review and meta-analysis of randomized controlled studies

Low-dose aspirin confers a survival benefit in patients with pathological advanced-stage oral squamous cell carcinoma

HSP70 regulates Eg5 distribution within the mitotic spindle and modulates the cytotoxicity of Eg5 inhibitors

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