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Showing 1–7 of 7 results
Advanced filters: Author: Shaocong Hou Clear advanced filters

  • Diabetic kidney disease (DKD) is the leading cause of end-stage kidney failure. This study shows that prolonged glucagon exacerbates lipid accumulation, promoting renal injury in early DKD, rather than lipid oxidation. Targeting glucagon signaling significantly inhibits DKD progression.

    • Xingfeng Liu
    • Jingwen Chen
    • Pingping Li
    ResearchOpen Access
    Nature Communications
    Volume: 16, P: 1-18

  • Fibroblast growth factors are involved in systemic glucose homeostasis and of interest for developing therapies for type 2 diabetes and associated metabolic diseases. Here the authors identify paracrine FGF4 as an anti-hyperglycemic FGF, which targets skeletal muscle to upregulate the glucose transporter GLUT4 cell surface abundance.

    • Lei Ying
    • Luyao Wang
    • Zhifeng Huang
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-14

  • Galectin-3, mainly produced and secreted by macrophages, is elevated in diabetes. Here, the authors show that galectin-3 directly interacts with voltage-gated channel auxiliary subunit gamma 1 (CACNG1) and blocks calcium transients and subsequent insulin secretion.

    • Qian Jiang
    • Qijin Zhao
    • Pingping Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • The tyrosine kinase receptor EphB4 is shown to interact with the insulin receptor to facilitate its endocytosis and degradation, thereby decreasing insulin signaling and promoting insulin resistance.

    • Xingfeng Liu
    • Kai Wang
    • Pingping Li
    Research
    Nature Metabolism
    Volume: 4, P: 1202-1213

  • β-Cell dysfunction is a hallmark of type 2 diabetes. Here, the authors show that trimethylamine N-oxide (TMAO (a microbiota metabolite)) induces β-cell dysfunction and type 2 diabetes in mice through NLRP3 inflammasome activation and calcium transients.

    • Lijuan Kong
    • Qijin Zhao
    • Pingping Li
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-17

  • Here, the authors show that the properties of the moiré excitons in twisted van der Waals bilayers of transition metal dichalcogenides are determined by the moiré reciprocal lattice period, and can be controlled via twist-angle tuning.

    • Long Zhang
    • Zhe Zhang
    • Hui Deng
    ResearchOpen Access
    Nature Communications
    Volume: 11, P: 1-8