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Showing 1–3 of 3 results
Advanced filters: Author: Shaoxiao Wang Clear advanced filters

  • The structure of the fully assembled yeast exocyst complex, which mediates the tethering of secretory vesicles to the plasma membrane during exocytosis, provides new insights to hierarchical complex assembly and the mechanism of vesicle tethering.

    • Kunrong Mei
    • Yan Li
    • Wei Guo
    Research
    Nature Structural & Molecular Biology
    Volume: 25, P: 139-146

  • Membrane fusion during exocytosis is mediated by interaction between SNARE proteins on vesicles and the cell membrane, but how SNARE complex assembly is initiated remains unknown. Here, the authors show that interaction of Sec3 with Sso2 on the plasma membrane promotes formation of an Sso2–Sec9 complex, an early step in SNARE assembly, likely by inhibiting Sso2 auto-inhibition.

    • Peng Yue
    • Yubo Zhang
    • Wei Guo
    ResearchOpen Access
    Nature Communications
    Volume: 8, P: 1-12