Nature Search

Rab27a regulates the transport of influenza virus membrane proteins to the plasma membrane

Using siRNA screening, Chen et al demonstrate that Rab27a and its effector SYTL4 mediate the transport of influenza viral membrane proteins to the plasma membrane, highlighting their role in virion assembly and identifying SYTL4 as a potential therapeutic target for antiviral drug development.

Tong Chen
Aotian Ouyang
Hongbo Zhou
ResearchOpen Access08 Jul 2025
Nature Communications

Volume: 16, P: 1-16
Lateral dispersion is required for circuit integration of newly generated dentate granule cells

Little is known regarding the initial development of newly generated neurons in the neurogenic zone. Here, the authors used advanced live imaging methods to show that adjacent newborn neurons coordinate their lateral dispersion via gap junctions, which is important for circuit integration

Jia Wang
Jia Shen
Shaoyu Ge
ResearchOpen Access25 Jul 2019
Nature Communications

Volume: 10, P: 1-9
A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy

Adult-born granule cells integrate in hippocampal circuitry and contribute to hippocampal function. Here, the authors show that a critical period of neuronal activity regulates aberrant neurogenesis to rewire hippocampal circuitry and drive seizures in a mouse model of epilepsy.

Zane R. Lybrand
Sonal Goswami
Jenny Hsieh
ResearchOpen Access03 Mar 2021
Nature Communications

Volume: 12, P: 1-14
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

Human ALS/FTD patient iPSC-derived neurons are used to uncover mechanisms by which C9ORF72 mutations cause neurodegeneration.

Yingxiao Shi
Shaoyu Lin
Justin K Ichida
Research05 Feb 2018
Nature Medicine

Volume: 24, P: 313-325
Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK

Mechanisms underlying the pathogenesis of nonalcoholic steatohepatitis are unclear. Here, the authors show that ROS-mediated DUSP22 degradation participates in the progression of fatty liver, contributing to the development of NASH and associated HCC via regulating FAK and its downstream ERK1/2 and NF-κB signaling cascade.

Chenxu Ge
Jun Tan
Minxuan Xu
ResearchOpen Access08 Oct 2022
Nature Communications

Volume: 13, P: 1-21
GABA regulates synaptic integration of newly generated neurons in the adult brain

Shaoyu Ge
Eyleen L. K. Goh
Hongjun Song
Research11 Dec 2005
Nature

Volume: 439, P: 589-593
The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes

Nonalcoholic steatohepatitis (NASH) is a chronic liver disease with complex disease mechanisms. Here the authors report that the E3 ubiquitin-protein ligase Trim31 mitigates development of NASH via inhibition of rhomboid 5 homolog 2 (Rhbdf2) in mice.

Minxuan Xu
Jun Tan
Bochu Wang
ResearchOpen Access25 Feb 2022
Nature Communications

Volume: 13, P: 1-20
Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning

The striatum has been shown to be important for learning, but its exact role is unclear. Here, the authors show that the striatum’s connection with the amygdala and its dopamine-dependent plasticity is necessary for fear learning.

Allen P. F. Chen
Lu Chen
Qiaojie Xiong
ResearchOpen Access09 Nov 2023
Nature Communications

Volume: 14, P: 1-14
Clonally related visual cortical neurons show similar stimulus feature selectivity

It has been proposed that, during development, clonally related neurons migrate along the same radial glial fibre to form clusters of functionally similar cells; here, sister neurons in the same radial clone are shown to have similar orientation preferences in mice, providing support for this hypothesis.

Ye Li
Hui Lu
Yang Dan
Research02 May 2012
Nature

Volume: 486, P: 118-121
Nigrostriatal dopamine pathway regulates auditory discrimination behavior

The auditory striatum, the tail portion of dorsal striatum, is implicated in decision-making. This study uncovers a phasic mechanism within the nigrostriatal system that regulates auditory decisions by modulating ongoing auditory perception.

Allen P. F. Chen
Jeffrey M. Malgady
Qiaojie Xiong
ResearchOpen Access08 Oct 2022
Nature Communications

Volume: 13, P: 1-15
Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging

l-Lactate is increasingly recognized as a key metabolite and signalling molecule in mammals, but the methods to investigate it in vivo have been limited. Here, authors report a pair of improved biosensors—one green and one red—for visualizing l-lactate both inside and outside of cells.

Yusuke Nasu
Abhi Aggarwal
Robert E. Campbell
ResearchOpen Access27 Oct 2023
Nature Communications

Volume: 14, P: 1-17
Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

Here, the authors show that microglia depletion results in unstable wakefulness and altered levels of ceramide, influencing microglia in the mouse thalamic reticular nucleus (TRN). Stable wakefulness can be restored by activation of the TRN or inhibition of ceramide production in the mouse brain.

Hanxiao Liu
Xinxing Wang
Qiaojie Xiong
ResearchOpen Access30 Jul 2021
Nature Communications

Volume: 12, P: 1-16
Medial geniculate body and primary auditory cortex differentially contribute to striatal sound representations

The precise role of auditory cortical and thalamic projections in the representation of sound in the auditory striatum is not known. Here, the authors show that silencing thalamic inputs lowers the gain of sound-evoked responses while cortical inputs only affect the best frequency responses of striatal neurons.

Liang Chen
Xinxing Wang
Qiaojie Xiong
ResearchOpen Access24 Jan 2019
Nature Communications

Volume: 10, P: 1-10
A role for primary cilia in glutamatergic synaptic integration of adult-born neurons

The authors describe the role of the primary cilium in the synaptic integration of adult-born hippocampal neurons. Preventing cilia formation in adult-born neurons causes deficits in dendritic refinement and synaptic formation.

Natsuko Kumamoto
Yan Gu
Shaoyu Ge
Research05 Feb 2012
Nature Neuroscience

Volume: 15, P: 399-405
XTRPC1-dependent chemotropic guidance of neuronal growth cones

Sangwoo Shim
Eyleen L Goh
Guo-li Ming
Research08 May 2005
Nature Neuroscience

Volume: 8, P: 730-735
Optical controlling reveals time-dependent roles for adult-born dentate granule cells

Newly generated dentate granule cells in the hippocampus at 4 weeks after their 'birth' are more plastic than existing neurons. The authors use a combined retroviral and optogenetic approach to show that silencing these 4-week-old cells, but not cells of other ages, impaired retrieval of hippocampal memory.

Yan Gu
Maithe Arruda-Carvalho
Shaoyu Ge
Research11 Nov 2012
Nature Neuroscience

Volume: 15, P: 1700-1706
Neural circuit mechanisms underlying aberrantly prolonged functional hyperemia in young Alzheimer’s disease mice

Thomas A. Kim
George Cruz
Shaoyu Ge
Research24 Jul 2024
Molecular Psychiatry

Volume: 30, P: 367-378
Dentate granule cells encode auditory decisions after reinforcement learning in rats

Jia Shen
Pan-Tong Yao
Qiaojie Xiong
ResearchOpen Access13 Jul 2021
Scientific Reports

Volume: 11, P: 1-12
Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

Parvalbumin-expressing interneurons regulate the activation and fate choice of adult neural stem cells.

Juan Song
Chun Zhong
Hongjun Song
Research29 Jul 2012
Nature

Volume: 489, P: 150-154
Depletion of primary cilia from mature dentate granule cells impairs hippocampus-dependent contextual memory

Soyoung Rhee
Gregory W. Kirschen
Shaoyu Ge
ResearchOpen Access28 Sept 2016
Scientific Reports

Volume: 6, P: 1-10
Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS

Changchang Xu
Lin Zhang
Yuguo Chen
Research12 Mar 2024
Cellular & Molecular Immunology

Volume: 21, P: 510-526
The temporal origin of dentate granule neurons dictates their role in spatial memory

Nuria Masachs
Vanessa Charrier
Djoher Nora Abrous
ResearchOpen Access15 Sept 2021
Molecular Psychiatry

Volume: 26, P: 7130-7140

Search

Rab27a regulates the transport of influenza virus membrane proteins to the plasma membrane

Lateral dispersion is required for circuit integration of newly generated dentate granule cells

A critical period of neuronal activity results in aberrant neurogenesis rewiring hippocampal circuitry in a mouse model of epilepsy

Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons

Hepatocyte phosphatase DUSP22 mitigates NASH-HCC progression by targeting FAK

GABA regulates synaptic integration of newly generated neurons in the adult brain

The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes

Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning

Clonally related visual cortical neurons show similar stimulus feature selectivity

Nigrostriatal dopamine pathway regulates auditory discrimination behavior

Lactate biosensors for spectrally and spatially multiplexed fluorescence imaging

Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

Medial geniculate body and primary auditory cortex differentially contribute to striatal sound representations

A role for primary cilia in glutamatergic synaptic integration of adult-born neurons

XTRPC1-dependent chemotropic guidance of neuronal growth cones

Optical controlling reveals time-dependent roles for adult-born dentate granule cells

Neural circuit mechanisms underlying aberrantly prolonged functional hyperemia in young Alzheimer’s disease mice

Dentate granule cells encode auditory decisions after reinforcement learning in rats

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

Depletion of primary cilia from mature dentate granule cells impairs hippocampus-dependent contextual memory

Neutrophil ALDH2 is a new therapeutic target for the effective treatment of sepsis-induced ARDS

The temporal origin of dentate granule neurons dictates their role in spatial memory

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