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Showing 1–4 of 4 results
Advanced filters: Author: Sharan Swarup Clear advanced filters

  • Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.

    • Sebastian Boland
    • Sharan Swarup
    • Robert V. Farese Jr
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-13

  • A proteomics analysis demonstrates that, during nutrient stress, mammalian cells prioritize degradation by autophagy of membrane proteins and identifies receptors that mediate this process at the Golgi and also have a role in Golgi remodelling during neuronal differentiation.

    • Kelsey L. Hickey
    • Sharan Swarup
    • J. Wade Harper
    ResearchOpen Access
    Nature
    Volume: 623, P: 167-174

  • Methods to assess organellar content are important. Here, Park et al develop a method for rapid isolation of early/sorting endosomes and demonstrate the application of the approach for analysis of endosomal proteomes and lipidomes, and for analysis of APP processing to Aβ via β and γ-Secretases.

    • Hankum Park
    • Frances V. Hundley
    • J. Wade Harper
    ResearchOpen Access
    Nature Communications
    Volume: 13, P: 1-21