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Advanced filters: Author: Sharon Guffy Clear advanced filters

An excited state underlies gene regulation of a transcriptional riboswitch

The use of chemical exchange saturation transfer NMR reveals a previously hidden excited conformational state of the fluoride riboswitch, providing a model in which ligand binding allosterically suppresses a linchpin base pair to activate transcription.

Bo Zhao
Sharon L Guffy
Qi Zhang
Research17 Jul 2017
Nature Chemical Biology

Volume: 13, P: 968-974
Macromolecular modeling and design in Rosetta: recent methods and frameworks

This Perspective reviews tools developed over the past five years in the macromolecular modeling, docking and design software Rosetta.

Julia Koehler Leman
Brian D. Weitzner
Richard Bonneau
Reviews01 Jun 2020
Nature Methods

Volume: 17, P: 665-680

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An excited state underlies gene regulation of a transcriptional riboswitch

Macromolecular modeling and design in Rosetta: recent methods and frameworks

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