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Showing 1–11 of 11 results
Advanced filters: Author: Sharon Moshitch-Moshkovitz Clear advanced filters

  • N6-methyladenosine (m6A) is an mRNA modification influencing gene expression. Advanced methodologies for mapping m6A enhance understanding of its dynamic roles and interactions. In this Primer, Moshitch-Moshkovitz et al. discuss various detection tools and analysis techniques facilitating insights into RNA epitranscriptomics.

    • Sharon Moshitch-Moshkovitz
    • Michal Sevilla-Sharon
    • Dan Dominissini
    Reviews
    Nature Reviews Methods Primers
    Volume: 4, P: 1-20

  • N6-methyladenosine (m6A) is the most prevalent internal modification in messenger RNA; here the human and mouse m6A modification landscape is presented in a transcriptome-wide manner, providing insights into this epigenetic modification.

    • Dan Dominissini
    • Sharon Moshitch-Moshkovitz
    • Gideon Rechavi
    Research
    Nature
    Volume: 485, P: 201-206

  • Here the m1A modification is discovered in messenger RNA and mapped at the transcriptome-wide level; the modification is conserved, dynamic, accumulates in structured regions around translation initiation sites upstream of the first splice site, and correlates with higher protein expression.

    • Dan Dominissini
    • Sigrid Nachtergaele
    • Chuan He
    Research
    Nature
    Volume: 530, P: 441-446

  • m6A and m6Am are two prevalent mRNA modifications which are target for removal by the fat mass and obesity gene FTO. Here the authors capture the differential profile of these two modifications in the liver of obese mice and identify dynamic translation regulation by the m6Am modification.

    • Moshe Shay Ben-Haim
    • Yishay Pinto
    • Gideon Rechavi
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-12

  • Iterative oxidation, elimination and dephosphorylation steps remove nucleotides from the 3′ end of RNA until a 2′-O-methylated ribose that cannot be oxidized is encountered and brings the process to a stop. High-throughput sequencing of these fragments exposes 2′-O-methyl sites at base resolution.

    • Qing Dai
    • Sharon Moshitch-Moshkovitz
    • Chuan He
    Research
    Nature Methods
    Volume: 14, P: 695-698

  • The impact of RNA modifications, such as RNA methylation, on gene expression and cellular function has been the subject of recent intense investigations. Here Dominissini and colleagues provide an overview of the mechanisms of such epitranscriptomic regulation and their functional consequences in the nervous system.

    • Ido Livneh
    • Sharon Moshitch-Moshkovitz
    • Dan Dominissini
    Reviews
    Nature Reviews Neuroscience
    Volume: 21, P: 36-51

  • Polymorphism of the FTO gene encoding an N6-methyladenosine (m6A) RNA demethylase was robustly associated with human obesity; however, the mechanism by which FTO affects metabolism, considering its emerging role in RNA modification, is still poorly understood. A new study published in Cell Research reports novel functions implicating FTO in the regulation of mRNA alternative splicing in the control of adipogenesis.

    • Moshe Shay Ben-Haim
    • Sharon Moshitch-Moshkovitz
    • Gideon Rechavi
    Research Highlights
    Cell Research
    Volume: 25, P: 3-4