Nature Search

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

An analysis of 24,202 critical cases of COVID-19 identifies potentially druggable targets in inflammatory signalling (JAK1), monocyte–macrophage activation and endothelial permeability (PDE4A), immunometabolism (SLC2A5 and AK5), and host factors required for viral entry and replication (TMPRSS2 and RAB2A).

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
ResearchOpen Access17 May 2023
Nature

Volume: 617, P: 764-768
Genetic analyses of pupation distance in Drosophila melanogaster

Marla B Sokolowski
Sharon J Bauer
Research01 Apr 1989
Heredity

Volume: 62, P: 177-183
Genomic investigations of unexplained acute hepatitis in children

An investigation using various methods reports an association between adeno-associated virus 2 and paediatric hepatitis of unknown aetiology.

Sofia Morfopoulou
Sarah Buddle
Judith Breuer
ResearchOpen Access30 Mar 2023
Nature

Volume: 617, P: 564-573
Earth’s soil harbours ancient carbon

Organic carbon in the top metre of Earth’s soils is far older than previously thought, averaging 4,800 years old. These radiocarbon-derived age estimates require us to recalibrate our expectations of ecosystem gains and losses of carbon.

Sharon A. Billings
Lígia F. T. de Souza
News & Views13 Jul 2020
Nature Geoscience

Volume: 13, P: 527-528
Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Erola Pairo-Castineira
Konrad Rawlik
J. Kenneth Baillie
Amendments and CorrectionsOpen Access11 Jul 2023
Nature

Volume: 619, P: E61
The mutational landscape of Staphylococcus aureus during colonisation

The authors applied a genomic and evolutionary approach to study Staphylococcus aureus in host adaptation during colonisation revealing signals of adaption in metabolic genes, in regulators of quorum-sensing and in known antibiotic targets.

Francesc Coll
Beth Blane
Ewan M. Harrison
ResearchOpen Access13 Jan 2025
Nature Communications

Volume: 16, P: 1-15
Erratum: South-South entrepreneurial collaboration in health biotech

Halla Thorsteinsdóttir
Christina C Melon
Peter A Singer
Amendments and Corrections07 Dec 2010
Nature Biotechnology

Volume: 28, P: 1308
Rho family proteins and Ras transformation: the RHOad less traveled gets congested

Irene M Zohn
Sharon L Campbell
Channing J Der
Reviews22 Sept 1998
Oncogene

Volume: 17, P: 1415-1438
Zika virus evolution and spread in the Americas

One hundred and ten Zika virus genomes from ten countries and territories involved in the Zika virus epidemic reveal rapid expansion of the epidemic within Brazil and multiple introductions to other regions.

Hayden C. Metsky
Christian B. Matranga
Pardis C. Sabeti
Research24 May 2017
Nature

Volume: 546, P: 411-415
Adeno-associated virus 2 infection in children with non-A–E hepatitis

A case–control study investigating the causes of recent cases of acute hepatitis of unknown aetiology in 32 children identifies an association between adeno-associated virus infection and host genetics in disease susceptibility.

Antonia Ho
Richard Orton
Emma C. Thomson
Research30 Mar 2023
Nature

Volume: 617, P: 555-563
Capturing sequence diversity in metagenomes with comprehensive and scalable probe design

A sensitive method to analyze metagenomes, CATCH, enables detection and characterization of diverse viral sequences, including the 356 viruses known to infect humans.

Hayden C. Metsky
Katherine J. Siddle
Christian B. Matranga
Research04 Feb 2019
Nature Biotechnology

Volume: 37, P: 160-168
Global disparities in SARS-CoV-2 genomic surveillance

In this study, the authors provide a global overview of SARS-CoV-2 genome sequencing, and estimate the proportion of cases sequenced and time to genome upload. They identify disparities and highlight the need to strengthen surveillance in lower and middle income countries.

Anderson F. Brito
Elizaveta Semenova
Nuno R. Faria
ResearchOpen Access16 Nov 2022
Nature Communications

Volume: 13, P: 1-13
Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Group 2 innate lymphoid cells (ILC2s) are generally considered to have pro-tumor functions. However, Belz and colleagues demonstrate that ILC2s have anti-melanoma effects due to their high production of the inflammatory cytokine granulocyte-macrophage colony-stimulating factor in the tumor microenvironment.

Nicolas Jacquelot
Cyril Seillet
Gabrielle T. Belz
Research07 Jun 2021
Nature Immunology

Volume: 22, P: 851-864
Transmitted duplication of 8p23.1–8p23.2 associated with speech delay, autism and learning difficulties

Mary Glancy
Angela Barnicoat
John C K Barber
Research20 Aug 2008
European Journal of Human Genetics

Volume: 17, P: 37-43
Keratoconus patients exhibit a distinct ocular surface immune cell and inflammatory profile

Sharon D’Souza
Archana Padmanabhan Nair
Swaminathan Sethu
ResearchOpen Access22 Oct 2021
Scientific Reports

Volume: 11, P: 1-16
South-South entrepreneurial collaboration in health biotech

A survey of entrepreneurial collaborations among health biotech firms in developing countries reveals a surprisingly high level of collaboration but a lack of emphasis on new or improved health biotech products and processes.

Halla Thorsteinsdóttir
Christina C Melon
Peter A Singer
Special Features01 May 2010
Nature Biotechnology

Volume: 28, P: 407-416
A genome-wide analysis of the response to inhaled β₂-agonists in chronic obstructive pulmonary disease

M Hardin
M H Cho
J Yates
Research27 Oct 2015
The Pharmacogenomics Journal

Volume: 16, P: 326-335
Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment

Marie Morimoto
Vikas Bhambhani
May Christine V. Malicdan
ResearchOpen Access10 Feb 2023
npj Genomic Medicine

Volume: 8, P: 1-16
Novel Therapeutic Modalities to Address Nondrugable Protein Interaction Targets

Errol B De Souza
Sharon T Cload
Dinah W Y Sah
Reviews27 Aug 2008
Neuropsychopharmacology

Volume: 34, P: 142-158

Search

GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

Genetic analyses of pupation distance in Drosophila melanogaster

Genomic investigations of unexplained acute hepatitis in children

Earth’s soil harbours ancient carbon

Author Correction: GWAS and meta-analysis identifies 49 genetic variants underlying critical COVID-19

The mutational landscape of Staphylococcus aureus during colonisation

Erratum: South-South entrepreneurial collaboration in health biotech

Rho family proteins and Ras transformation: the RHOad less traveled gets congested

Zika virus evolution and spread in the Americas

Adeno-associated virus 2 infection in children with non-A–E hepatitis

Capturing sequence diversity in metagenomes with comprehensive and scalable probe design

Global disparities in SARS-CoV-2 genomic surveillance

Blockade of the co-inhibitory molecule PD-1 unleashes ILC2-dependent antitumor immunity in melanoma

Transmitted duplication of 8p23.1–8p23.2 associated with speech delay, autism and learning difficulties

Keratoconus patients exhibit a distinct ocular surface immune cell and inflammatory profile

South-South entrepreneurial collaboration in health biotech

A genome-wide analysis of the response to inhaled β₂-agonists in chronic obstructive pulmonary disease

Bi-allelic ATG4D variants are associated with a neurodevelopmental disorder characterized by speech and motor impairment

Novel Therapeutic Modalities to Address Nondrugable Protein Interaction Targets

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