Methods for specific gene silencing have advanced as far as clinical trials, but a similar set of tools does not exist for increasing gene expression. Modarresi et al. demonstrate gene-specific upregulation in vivo by treating mice with oligonucleotides that inhibit the function of natural antisense transcripts.
- Farzaneh Modarresi
- Mohammad Ali Faghihi
- Claes Wahlestedt
