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Showing 1–7 of 7 results
Advanced filters: Author: Shaurya Dhingra Clear advanced filters

  • T cell activation is a process that requires extra nutrients, which could be difficult to source from the tumor microenvironment in competition with tumor cells. Here authors increase the metabolic fitness of CAR-T cells by stable overexpression of the glucose transporter GLUT1, which allows them to increase their glucose intake and enhances their antitumour function.

    • Justin A. Guerrero
    • Dorota D. Klysz
    • Crystal L. Mackall
    ResearchOpen Access
    Nature Communications
    Volume: 15, P: 1-20

  • Combination of TCR or CAR T cells expressing the engineered CD47 variant 47E with anti-CD47 antibody therapy results in synergistic antitumour efficacy due to T cell resistance to clearance by macrophages, while maintaining macrophage recruitment into the tumour microenvironment.

    • Sean A. Yamada-Hunter
    • Johanna Theruvath
    • Crystal L. Mackall
    ResearchOpen Access
    Nature
    Volume: 630, P: 457-465

  • Profiling the immune responses of 56 volunteers vaccinated with BNT162b2 reveals how this mRNA vaccine primes the innate immune system to mount a potent response to SARS-CoV-2 after booster immunization.

    • Prabhu S. Arunachalam
    • Madeleine K. D. Scott
    • Bali Pulendran
    Research
    Nature
    Volume: 596, P: 410-416

  • Infection with SARS-CoV2 and the development of Coronavirus disease 2019 (COVID-19) has been linked to induction of autoimmunity and autoantibody production. Here the authors characterise the new-onset IgG autoantibody response in hospitalised patients with COVID-19 which they correlate to the magnitude of the SARS-CoV2 response.

    • Sarah Esther Chang
    • Allan Feng
    • Paul J. Utz
    ResearchOpen Access
    Nature Communications
    Volume: 12, P: 1-15

  • The combination of anti-GD2 and CD47 blockade mediates robust anti-tumor activity in mouse models of neuroblastoma, osteosarcoma and small-cell lung cancer by reorienting macrophage activity toward tumor cell phagocytosis.

    • Johanna Theruvath
    • Marie Menard
    • Robbie G. Majzner
    Research
    Nature Medicine
    Volume: 28, P: 333-344